题目：Nano and Biomechanics in Cell and Tissue engineering

时间：2014年12月29日（周一）10:00

地点：信电楼215室

报告人：Dr. Jinju Chen

Brief Biography：

Dr. Chen completed her PhD thesis within 2 years and 9 months, sponsored by Overseas Research Scholarship and International Research Studentship.  After obtaining her PhD in fracture mechanics of nano-films at Newcastle University, she worked as a Post-doc research associate at Newcastle University (Nano Lab) and Queen Mary University of London (Cell & Tissue Engineering Lab).  In Sept. 2011, she got a faculty position in School of Mechanical & System Engineering at Newcastle University. She has 42 publications, five of which are editorial invited papers. One paper has been highlighted as one of the top papers in J. Phys. D: Appl. Phys. in 2007. She has delivered over 20 invited talks at conferences and seminars.  She also reviews research grants and examines PhDs nationally and internationally. She was academic visitor in Max-Planck-Institut für Eisenforschung, Nanyang Technological University, and Loughborough University. She received European Society of Biomechanics Travel Award and International Travel Grant (The Royal Society) in 2010. She served as a guest editor for Thin Solid Films. She also chairs and co-organizes conference sessions in biomechanics and nanomechanics in various conferences.  Newcastle University has recently received a prestigious EPSRC award  (£5.6m): An New Frontier in Design: The Simulation of Open Engineered Biological Systems.  Within this grant, she is the theme leader of biomechanics.  She is currently supervising two post-doctoral research fellows and three PhD students.

Abstract:

Cell mechanics and cell-materials interactions are important for disease diagnosis and tissue engineering. The synergistic combination of computational modelling and experimental approaches allows exploring phenomena in cell mechanics and mechanotransduction that are not easily accessible with experimental methods alone. A hybrid modelling–nanomechanical testing approach enables determining the viscoelastic properties of the living cells, which is useful to quantify the biomechanical effects of drug treatment, diseases and aging. Such a nanomechanical method can also be applied to assess the micro(nano)scale mechanical properties of engineered bone  and scaffold materials which could further the understanding cell-materials interactions.  In addition, this talk will cover how cells respond to two-dimensional and three-dimensional micromechanical environment, which will help a better understanding of the mechanotransduction and  provide valuable guide for optimising  scaffold design.